Penerbangan rute Jakarta – Kairo ditempuh melalui Bandara Soekarno Hatta (CGK) di Cengkareng – Jakarta Menuju ke Bandara Internasional Kairo (CAI) di Kairo – Mesir. Penerbangan langsung di rute ini membutuhkan waktu tempuh rata-rata sepanjang 11 jam 15 menit tanpa transit. Maskapai yang tersedia untuk rute penerbangan Jakarta – Kairo, diantaranya adalah Qatar Airways, Emirates, Qatar Airways, Egypt Air, Saudia, Garuda Indonesia, Etihad Airways, Thai Airways, Turkish Airlines, dan Kuwait Airways.
Dalam sehari, tersedia sekitar 40 jadwal keberangkatan untuk rute ini. Untuk informasi lebih rinci terkait jadwal keberangkatan pesawat adalah sebagai berikut,
| Nama Maskapai | Kode Penerbangan | Berangkat | Tiba |
| Qatar Airways | QR955 | 12.20 AM | 04.25 AM |
| Qatar Airways | QR1303 | 09.00 AM | 11.15 AM |
| Emirates | EK359 | 12.40 AM | 05.35 AM |
| Emirates | EK927 | 08.50 AM | Bottom of Form
10.40 AM |
| Etihad Airways | EY471 | 01.30 AM | 07.00 AM |
| Etihad Airways | EY653 | 10.05 AM | 12.00 PM |
| Qatar Airways | QR959 | 06.10 AM | 10.35 AM |
| Egypt Air | MS936 | 01.35 PM | 03.55 PM |
| Emirates | EK369 | 07.25 AM | 12.05 PM |
| Emirates | EK923 | 03.00 PM | 04.50 PM |
| Saudia | SV819 | 10.10 AM | 03.30 PM |
| Saudia | SV305 | 08.20 PM | 09.25 PM |
| Garuda Indonesia | GA980 | 11.40 AM | 05.30 PM |
| Saudia | SV305 | 08.30 PM | 09.35 PM |
| Saudia | SV819 | 12.55 PM | 06.20 PM |
| Egypt Air | MS678 | 08.30 PM | 09.20 PM |
| Saudia | SV825 | 01.00 PM | 06.25 PM |
| Egypt Air | MS678 | 08.30 PM | 09.20 PM |
| Saudia | SV813 | 01.00 PM | 05.40 PM |
| Saudia | SV315 | 09.10 PM | 10.50 PM |
| Garuda Indonesia | GA816 | 01.50 PM | 05.00 PM |
| Egypt Air | MS961 | 09.25 PM | 05.05 AM (+1) |
| Saudia | SV815 | 03.35 PM | 08.55 PM |
| Saudia | SV307 | 12.10 AM | 01.15 AM |
| Saudia | SV823 | 03.35 PM | 08.15 PM |
| Saudia | SV337 | 10.05 PM | 11.45 PM |
| Saudia | SV821 | 03.35 PM | 09.30 PM |
| Egypt Air | MS676 | 02.25 AM | 03.25 AM |
| Oman Air | WY848 | 03.45 PM | 08.35 PM |
| Oman Air | WY407 | 10.35 PM | 01.00 AM (+1) |
| Garuda Indonesia | GA982 | 04.25 PM | 10.15 PM |
| Egypt Air | MS644 | 12.30 AM | 01.40 AM |
| Garuda Indonesia | GA864 | 04.50 PM | 08.10 PM |
| Egypt Air | MS961 | 12.55 AM | 05.05 AM |
| Etihad Airways | EY475 | 05.15 PM | 10.45 PM |
| Etihad Airways | EY651 | 12.45 AM | 02.40 AM |
| Thai Airways | TG436 | 06.50 PM | 10.20 PM |
| Egypt Air | MS961 | 12.55 AM | 05.05 AM |
| Egypt Air | MS961 | 07.10 PM | 05.50 AM (+1) |
| Turkish Airlines | TK57 | 08.35 PM | 05.10 AM (+1) |
| Turkish Airlines | TK690 | 06.45 AM | 07.55 AM |
| Kuwait Airways | KU416 | 11.05 PM | 06.00 AM (+1) |
| Kuwait Airways | KU1801 | 09.00 AM | 10.45 AM |